IRF2BP2

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IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene.

Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Action

IRF2BP2 interacts with the C-terminal transcriptional repression domain of IRF2.

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities.

Represses the NFAT1-dependent transactivation of NFAT-responsive promoters.

Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.

Diseases

Diseases associated with IRF2BP2 include Mesenchymal Chondrosarcoma and Common Variable Immunodeficiency.

Expression

Upregulated - mainly after 1 hour after exercise.

IRF2BP2 expression

Coregulation

Gene SIAH2 MNT WBP1L BHLHE40 SLC25A25 ELMSAN1 PIP5K1C ARID5B CTGF KLF11 CX3CL1 LRRC8A
r 0.7785532 0.7768744 0.7723620 0.7699279 0.7516998 0.7476651 0.7470779 0.7165333 0.7135609 0.7129015 0.7070233 0.7015876
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