WorkingNotes
WorkingNotes
Working notes on modeling processes in human skeletal muscle during exercise
The main task arising before us is incredibly complex and cannot be fully resolved at this time. But an interesting challenge must be a little crazy.
The working notes: The model development roadmap.
Data quality assessment
One of the side effects of modelling is the indirect assessment of data quality in various subject areas. A search for relevant numerical data reveals that even relatively well-studied areas lack enough suitable data, despite hundreds of studies. Therefore, modelling is useful not only as a tool for creating applied models but also in itself, as a tool for assessing the available data quality.
The amount of data available to date, compared to the outstanding issues, suggests that a fairly complete model will be at least 90% hypothetical. Such a model cannot be truly validated. Its adequacy can only be confirmed by the general behaviour of the known variables/indicators.
The summary diagram of some data problems for modeling.
The diagram of protein localization data problems.
Localization_of_proteins_in_the_cytoplasm_of_myocytes.png
The working notes: AMPK localization, questions.
AMPK_localization,_questions.pdf
The working notes: Data for fitting, problems, Different pH dynamics in MRS studies and when measuring pH using biopsy, different La dynamics.
