Difference between revisions of "WorkingNotes"
(→WorkingNotes) |
|||
| (29 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
| − | === | + | === Working Notes === |
| − | |||
| − | |||
| + | ''' Working notes on modeling the processes on metabolic, signaling and gene expression regulation levels in human skeletal muscle during an exercise ''' | ||
| − | The | + | The major challenge facing us is incredibly complex and cannot be comprehensively resolved at this time. But any interesting research challenge must be a little crazy. |
| − | |||
| − | The | + | The working notes: A roadmap of the Model development. [https://drive.google.com/file/d/1VY0YXOfo5gZ8m1bNxRYvg93iEnmCxQOI Link...] |
| − | + | ''' Data quality assessment ''' | |
| − | + | One of the side effects of the modeling is the indirect assessment of data quality in various subject areas. Our exploration of relevant numerical data reveals that even relatively well-studied fields lack enough suitable qualitative and quantitative data required for model construction, fitting and validation. Therefore, modeling process is useful not only as a tool to build applied computational models but also as an indirect way to assess the quality of available data. | |
| + | Compared to the outstanding issues, the amount of suitable data available to date suggests that a fairly complete model will be at least 90% hypothetical. Such a model cannot be truly validated. Its adequacy can only be confirmed by the general behaviour of the known variables/indicators. | ||
| − | |||
| − | [https://drive.google.com/file/d/ | + | The working notes: The summary of data problems for modeling. [https://drive.google.com/file/d/1dwXYtNusPaJccnMUA4YT8YPRe_OE3cTM Link...] |
| − | The working notes: | + | The working notes: The summary of protein localization data problems. [https://drive.google.com/file/d/1i9ckmLjFunXtdY1ECnEzZ0XeBAa6eakQ Link...] |
| − | |||
| + | The working notes: AMPK localization, open questions. [https://drive.google.com/file/d/1IeM_MqtkIfjcC3H0zeZjj5XlCxCxG95c/view?usp=sharing Link...] | ||
| − | |||
| − | [https://drive.google.com/file/d/ | + | The working notes: Data for fitting, problems, Different pH dynamics in MRS studies and pH measurements using biopsy, different La dynamics. |
| + | [https://drive.google.com/file/d/1n4wi4N-AC0TTNf5b-9XE44Tsfl4mSlO-/view?usp=sharing Link...] | ||
| + | |||
| + | |||
| + | The working notes: Results obtained using a mechanistic approach to finding the X-factor for PGC-1α. [https://drive.google.com/file/d/1biK4QkzGjuJQEhw4I4S2CY7YLNBTaE8O Link...] | ||
| + | |||
| + | |||
| + | The working notes: Potential causes of temporary shifts in the expression of genes after exercise. [https://drive.google.com/file/d/1MKZhgFftL1iq5Kd32N5LczZce0g_uBd7/view?usp=sharing Link...] | ||
| + | |||
| + | |||
| + | ''' These notes will be updated according to our review of new published data on these topics ''' | ||
Latest revision as of 02:20, 22 August 2021
Working Notes
Working notes on modeling the processes on metabolic, signaling and gene expression regulation levels in human skeletal muscle during an exercise
The major challenge facing us is incredibly complex and cannot be comprehensively resolved at this time. But any interesting research challenge must be a little crazy.
The working notes: A roadmap of the Model development. Link...
Data quality assessment
One of the side effects of the modeling is the indirect assessment of data quality in various subject areas. Our exploration of relevant numerical data reveals that even relatively well-studied fields lack enough suitable qualitative and quantitative data required for model construction, fitting and validation. Therefore, modeling process is useful not only as a tool to build applied computational models but also as an indirect way to assess the quality of available data.
Compared to the outstanding issues, the amount of suitable data available to date suggests that a fairly complete model will be at least 90% hypothetical. Such a model cannot be truly validated. Its adequacy can only be confirmed by the general behaviour of the known variables/indicators.
The working notes: The summary of data problems for modeling. Link...
The working notes: The summary of protein localization data problems. Link...
The working notes: AMPK localization, open questions. Link...
The working notes: Data for fitting, problems, Different pH dynamics in MRS studies and pH measurements using biopsy, different La dynamics.
Link...
The working notes: Results obtained using a mechanistic approach to finding the X-factor for PGC-1α. Link...
The working notes: Potential causes of temporary shifts in the expression of genes after exercise. Link...
These notes will be updated according to our review of new published data on these topics
