Difference between revisions of "IRF2BP2"
From Muscle
(Created page with "IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms....") |
|||
| Line 11: | Line 11: | ||
Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle. | Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle. | ||
| + | |||
| + | ====Pathways==== | ||
| + | ... todo | ||
====Diseases==== | ====Diseases==== | ||
Revision as of 17:56, 23 January 2018
IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Action
IRF2BP2 interacts with the C-terminal transcriptional repression domain of IRF2.
Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities.
Represses the NFAT1-dependent transactivation of NFAT-responsive promoters.
Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.
Pathways
... todo
Diseases
Diseases associated with IRF2BP2 include Mesenchymal Chondrosarcoma and Common Variable Immunodeficiency.
Expression
Upregulated - mainly after 1 hour after exercise.
Coregulation
| Gene | SIAH2 | MNT | WBP1L | BHLHE40 | SLC25A25 | ELMSAN1 | PIP5K1C | ARID5B | CTGF | KLF11 | CX3CL1 | LRRC8A |
| r | 0.7785532 | 0.7768744 | 0.7723620 | 0.7699279 | 0.7516998 | 0.7476651 | 0.7470779 | 0.7165333 | 0.7135609 | 0.7129015 | 0.7070233 | 0.7015876 |
