Difference between revisions of "GCH1"
From Muscle
(Created page with "This gene encodes a member of the GTP cyclohydrolase family. ====Action==== The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthes...") |
|||
| (One intermediate revision by the same user not shown) | |||
| Line 9: | Line 9: | ||
May modify pain sensitivity and persistence <cite>1</cite>. | May modify pain sensitivity and persistence <cite>1</cite>. | ||
| + | ====Kinetics==== | ||
| + | KM=116 µM for GTP <cite>2</cite>. | ||
====Pathways==== | ====Pathways==== | ||
| + | 7,8-dihydroneopterin triphosphate biosynthesis | ||
eNOS activation | eNOS activation | ||
| Line 18: | Line 21: | ||
<biblio> | <biblio> | ||
#1 pmid=24373571 | #1 pmid=24373571 | ||
| + | #2 pmid=2500984 | ||
</biblio> | </biblio> | ||
| Line 24: | Line 28: | ||
[[File:GCH1.png|GCH1 expression]] | [[File:GCH1.png|GCH1 expression]] | ||
| + | |||
| + | [[Category:muscle_DEGs]] | ||
Latest revision as of 14:34, 26 January 2018
This gene encodes a member of the GTP cyclohydrolase family.
Action
The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate.
BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases.
GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
May modify pain sensitivity and persistence [1].
Kinetics
KM=116 µM for GTP [2].
Pathways
7,8-dihydroneopterin triphosphate biosynthesis eNOS activation
Diseases
Hyperphenylalaninemia, Bh4-Deficient, B and Dystonia, Dopa-Responsive, With Or Without Hyperphenylalaninemia.
References
- George SZ, Parr JJ, Wallace MR, Wu SS, Borsa PA, Dai Y, and Fillingim RB. Biopsychosocial influence on exercise-induced injury: genetic and psychological combinations are predictive of shoulder pain phenotypes. J Pain. 2014 Jan;15(1):68-80. DOI:10.1016/j.jpain.2013.09.012 |
- Shen RS, Alam A, and Zhang YX. Human liver GTP cyclohydrolase I: purification and some properties. Biochimie. 1989 Mar;71(3):343-9. DOI:10.1016/0300-9084(89)90006-0 |
Expression
Upregulated - after 1 hour after exercises.
