http://muscle.biouml.org/index.php?action=history&feed=atom&title=SERPINH1SERPINH1 - Revision history2026-05-16T07:07:40ZRevision history for this page on the wikiMediaWiki 1.29.2http://muscle.biouml.org/index.php?title=SERPINH1&diff=31&oldid=prevFedor: Created page with "Serpin H1 Synonim: 47 kDa heat shock protein Member of the serpin superfamily of serine proteinase inhibitors. ====Action==== Binds specifically to collagen. Could be involve..."2018-01-27T14:56:02Z<p>Created page with "Serpin H1 Synonim: 47 kDa heat shock protein Member of the serpin superfamily of serine proteinase inhibitors. ====Action==== Binds specifically to collagen. Could be involve..."</p>
<p><b>New page</b></p><div>Serpin H1<br />
Synonim: 47 kDa heat shock protein<br />
<br />
Member of the serpin superfamily of serine proteinase inhibitors.<br />
====Action====<br />
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.<br />
<br />
The change of HSP47, collagen specific molecular chaperone, expression in rat skeletal muscle may regulate collagen production with gravitational conditions<cite>1</cite>.<br />
<br />
The gravity-regulated HSP47 may play a role in the maintenance of the extracellular matrix by modulating collagen production at the primary stage of adaptation<cite>2</cite>..<br />
<br />
HSP47 may be involved in the repair or regeneration of muscle fibers in addition to the fibrotic change in the connective tissue<cite>3</cite>.<br />
====Pathways====<br />
====Diseases====<br />
Osteogenesis Imperfecta, Type X and Preterm Premature Rupture Of The Membranes<br />
====References====<br />
<biblio><br />
#1 pmid=15858365<br />
#2 pmid=17054723<br />
#3 pmid=17324572<br />
</biblio><br />
<br />
====Expression====<br />
Upregulated - after 1 hour after exercises and after training.<br />
<br />
[[File:SERPINH1.png|SERPINH1 expression]]<br />
<br />
Hsp47 mRNA levels in cultured myoblasts increased significantly with hypergravity treatment at 40G for 2 h, and decreased with microgravity treatment at almost 0G for 1-2 h.<br />
Collagen mRNA levels were also altered, although changes were slower and less pronounced compared with those for HSP47. <cite>3</cite>.<br />
<br />
[[Category:muscle_DEGs]]</div>Fedor