http://muscle.biouml.org/index.php?action=history&feed=atom&title=LRRC10 2026-05-16T07:07:25Z Revision history for this page on the wiki MediaWiki 1.29.2 http://muscle.biouml.org/index.php?title=LRRC10&diff=19&oldid=prev 2018-01-26T08:58:15Z

<p>Created page with &quot;Leucine-rich repeat containing protein (LRRC)10 is a cardiac-specific member of the LRRC superfamily. ====Action==== LRRC10 has no other known functional domains other than i...&quot;</p> <p><b>New page</b></p><div>Leucine-rich repeat containing protein (LRRC)10 is a cardiac-specific member of the LRRC superfamily.<br /> <br /> ====Action====<br /> LRRC10 has no other known functional domains other than its LRRs (28 in &lt;cite&gt;1&lt;/cite&gt;), suggesting that it mediates its biological functions by interacting with other proteins.<br /> <br /> LRRC10 interacts with actin and α-actinin in the heart (8) and localizes at the dyad region where the Z-disc comes into close juxtaposition to the T-tubule and sarcoplasmic reticulum (8, 28).<br /> <br /> This places LRRC10 at a mechanosensitive signaling hub in cardiomyocytes (19).<br /> <br /> Lrrc10−/− mice exhibit increased cardiac growth in response to pressure overload &lt;cite&gt;1&lt;/cite&gt;.<br /> <br /> Lrrc10−/− myocytes have reduced single cell contractility in response to adrenergic stimulation, <br /> indicating that LRRC10 is indispensable for the response of the mammalian heart to biomechanical stress &lt;cite&gt;1&lt;/cite&gt;.<br /> <br /> Deletion of Lrrc10 greatly exacerbates cardiac dysfunction in response to pressure overload &lt;cite&gt;1&lt;/cite&gt;.<br /> <br /> His150 of LRRC10 mediates its interaction with actin in the heart and that the interaction of LRRC10 with actin is reduced after pressure overload,<br /> suggesting a potential mechanosensing function for LRRC10 &lt;cite&gt;1&lt;/cite&gt;.<br /> <br /> LRRC10 may serve as a cardiomyocyte-specific scaffolding protein to tether important structural or signaling molecules to mediate appropriate responses to mechanical stress. <br /> Z-disc proteins such as muscle LIM protein (2, 29), Cypher (56, 57), and telethonin (29, 30) are thought to compose a mechanosensory signalosome <br /> that allows the cardiomyocyte to internally sense and respond to mechanical stretch or strain &lt;cite&gt;1&lt;/cite&gt;. <br /> <br /> Moreover, LRRC39, a striated muscle-specific LRRC, acts as a mechanosensor at the cardiomyocyte M-line by regulating serum response factor-dependent transcription (51).<br /> <br /> ====Pathways====<br /> The cardiomyocyte-specific expression of Lrrc10 is regulated by Nkx2.5, GATA4, and serum response factor (7).<br /> <br /> ====Diseases====<br /> Mutations in the LRRC10 gene have been recently linked to human dilated cardiomyopathy (43).<br /> <br /> ====Expression====<br /> Lrrc10 is expressed exclusively in cardiomyocytes &lt;cite&gt;1&lt;/cite&gt;.<br /> <br /> ====References====<br /> &lt;biblio&gt;<br /> #1 pmid=26608339<br /> #2 pmid=<br /> &lt;/biblio&gt;<br /> <br /> [[Category:mechanosensor]]</div>

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