Fedor: Created page with "Guanylate-binding protein 1 ====Action==== Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions:
GTP + H2O = GDP + phosphate Exhibits antiviral activity against in..."

2018-01-27T16:48:13Z

Created page with "Guanylate-binding protein 1 ====Action==== Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions: GTP + H2O = GDP + phosphate Exhibits antiviral activity against in..."

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Guanylate-binding protein 1

====Action====
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions:
 GTP + H2O = GDP + phosphate

Exhibits antiviral activity against influenza virus.

Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.

GBP-1 is both necessary and sufficient for the inhibitory effects of IFN-γ on cell proliferation, migration, and invasion, as shown in endothelial cells and epithelial tumor cells
(17, 19, 34,–37 in <cite>1</cite>).

Purified GBP-1 and actin bound to each other, and this interaction was sufficient to impair the formation of actin filaments in vitro <cite>1</cite>.

Cosedimentation and band shift analyses demonstrated that GBP-1 binds robustly to globular actin and slightly to filamentous actin.
This indicated that GBP-1 may induce actin remodeling via globular actin sequestering and/or filament capping.<cite>1</cite>..

GBP-1 colocalized with actin at the subcellular level and was both necessary and sufficient for the extensive remodeling
of the fibrous actin structure observed in IFN-γ-exposed cells. These effects were dependent on the oligomerization and the GTPase activity of GBP-1<cite>1</cite>.

An artificial backwards-moving myosin from three pre-existing molecular building blocks:
 - a forward-moving class I myosin motor domain,
 - a directional inverter formed by a four-helix bundle segment of human guanylate-binding protein-1
 - an artificial lever arm formed by two alpha-actinin repeats.
 Reverse-direction movement of myosins can be achieved simply by rotating the direction of the lever arm 180 degrees <cite>2</cite>.

====Pathways====
GBP-1 is a major IFN-γ-induced protein in eukaryotic cells (22, 66 in <cite>1</cite>).

====Diseases====
Chronic Active Epstein-Barr Virus Infection and Aneurysmal Bone Cysts.

====References====
<biblio>
#1 pmid=24190970
#2 pmid=14765199
</biblio>

====Expression====
Upregulated - after 1 hour after exercises and after training.

[[File:GBP1.png|GBP1 expression]]

[[Category:muscle_DEGs]]

GBP1 - Revision history

Fedor: Created page with "Guanylate-binding protein 1 ====Action==== Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions: GTP + H2O = GDP + phosphate Exhibits antiviral activity against in..."

Fedor: Created page with "Guanylate-binding protein 1 ====Action==== Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions:
GTP + H2O = GDP + phosphate Exhibits antiviral activity against in..."